monsterpax.blogg.se - Cortisol is secreted by the adrenal cortex

In addition, knowledge from histological and molecular studies in patients with aldosterone- and cortisol-co-secreting tumors challenges some concepts of the development of adrenal autonomy. adrenal venous sampling, screening of familial forms of PA on the basis of serum 18-hydroxy-cortisol (18-OH-F) determination, and provoke glucocorticoid deficiency after surgical removal of the tumor. Overt or subclinical glucocorticoid hypersecretion may interfere with diagnostic studies, e.g. This article reviews published data on aldosterone- and cortisol-co-secreting tumors and shows that pre-operative diagnosis of such a lesion is beneficial for patients. However, clinically relevant autonomous aldosterone production rarely originates in adrenal tumors, compromised of zona glomerulosa cells only. A general screening for excess secretion of other hormones is not recommended. It is further recommended to demonstrate unilateral disease because of its consequence for therapy.

Saving Earth Britannica Presents Earth’s To-Do List for the 21st Century.Current guidelines suggest proving angiotensin-independent aldosterone secretion in patients with primary aldosteronism (PA).

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